Janmet 1000mg Tablet

✔️ Uses of Janmet 1000mg Tablet

• Type 2 diabetes Mellitus

✔️ How does Janmet 1000mg Tablet work?

• Janmet 1000 contains two antidiabetic medicines: Sitagliptin and Metformin.
• Sitagliptin helps the pancreas produce more insulin, facilitates insulin use by the body, and reduces excess sugar production by the liver.
• Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and increases peripheral glucose uptake.

✔️ Side Effects of Janmet 1000mg Tablet

Common adverse reactions include diarrhea, upper respiratory tract infection, headache, hypoglycemia, nausea/vomiting, flatulence, stomach discomfort, indigestion, asthenia, and headache.

✔️ Quick Suggestions:

• To reduce the risk of having an upset stomach, it's advisable to take Janmet 1000mg Tablet with food. This can help minimize any gastrointestinal discomfort that may occur as a side effect.
• Compared to some other diabetes medicines, Janmet 1000mg Tablet is associated with a lower risk of weight gain and low blood sugar (hypoglycemia). However, it's essential to monitor your blood sugar levels regularly and follow your doctor's instructions to maintain stable glucose levels.
• If you are scheduled to undergo surgery under general anesthesia, it's crucial to inform your doctor about your diabetes treatment. They can provide guidance on managing your blood sugar levels before, during, and after the surgery to ensure your safety and well-being.
• Lactic acidosis is a rare but serious condition that may occur with Janmet 1000mg Tablet. If you experience symptoms such as deep or rapid breathing, persistent nausea, vomiting, and stomach pain, contact your doctor immediately. Lactic acidosis is characterized by an excess of lactic acid in the blood and requires prompt medical attention.

✔️ Indications:

This medication is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate. It should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. It has not been studied in patients with a history of pancreatitis.

✔️ Pharmacology

Janmet 1000mg Tablet combines two antihyperglycemic agents with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that slows the inactivation of incretin hormones, leading to increased insulin release and decreased glucagon levels in a glucose-dependent manner. Metformin, on the other hand, reduces hepatic glucose production, decreases intestinal glucose absorption, and increases peripheral glucose uptake and utilization.

✔️ Dosage & Administration of Janmet 1000mg Tablet

The dosage of this tablet should be individualized based on the patient's current regimen, effectiveness, and tolerability, not exceeding the maximum recommended daily doses of 100 mg sitagliptin and 2000 mg metformin. It is typically given twice daily with meals, with gradual dose escalation to reduce gastrointestinal side effects associated with metformin.

The recommended starting dose in patients not currently treated with metformin is 50 mg sitagliptin/500 mg metformin hydrochloride twice daily. The starting dose in patients already on metformin should provide 50 mg sitagliptin twice daily (100 mg total daily dose) and the current metformin dose. For patients taking metformin 850 mg twice daily, the recommended starting dose of this tablet is 50 mg sitagliptin/1000 mg metformin hydrochloride twice daily.

✔️ Interaction

There are potential interactions with cationic drugs, phenprocoumon, and levothyroxine. Caution is advised when using this medication in combination with these drugs.

✔️ Contraindications

This tablet is contraindicated in patients with renal disease or dysfunction, acute or chronic metabolic acidosis, a history of serious hypersensitivity reactions to this tablet or sitagliptin, and during radiologic studies involving intravascular administration of iodinated contrast materials.

✔️ Pregnancy & Lactation

Use during pregnancy is recommended only if clearly needed, and caution should be exercised when used by nursing women as it is not known whether sitagliptin is excreted in human breast milk.

✔️ Precautions & Warnings

Lactic acidosis is a potential risk, especially in conditions like sepsis, dehydration, excess alcohol intake, hepatic impairment, renal impairment, and acute congestive heart failure. Regular monitoring of thyroid-stimulating hormone (TSH) levels and vitamin B12 levels is recommended. It should be temporarily discontinued during periods of stress and reduced fluid and food intake. Caution is advised in cases of hypersensitivity reactions, and the drug should be discontinued if severe reactions occur.

✔️ Storage Conditions

Store below 25°C in a dry place away from light and keep out of the reach of children.